Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Preparation and characterization of a complex of paeonol and hydroxypropyl-ß-cyclodextrin

Chungang Chen¹ , Xinjuan Xu², Xinjuan Li¹, Hanjun Ma¹

¹School of Food Science; ²School of Life Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China.

For correspondence:- Chungang Chen Email: ccg28@126.com

Received: 17 April 2015 Accepted: 2 August 2015 Published: 29 September 2015

Citation: Chen C, Xu X, Li X, Ma H. Preparation and characterization of a complex of paeonol and hydroxypropyl-ß-cyclodextrin. Trop J Pharm Res 2015; 14(9):1565-1571 doi: 10.4314/tjpr.v14i9.4

© 2015 The authors.
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Abstract

Purpose: To improve the solubility of paeonol in water by complexing with hydroxypropyl-β-cyclodextrin (HP-β-CD) and also to characterize the physicochemical properties of the complex.

Methods: The complex of paeonol and HP-β-CD was prepared by freeze-drying method. Its physicochemical properties were studied by phase-solubility method, ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), scanning electron microscopy (SEM), x-ray diffractometry (XRD) and thermogravimetric/differential scanning calorimetry (TG/DSC).

Results: The phase-solubility results showed that paeonol formed a 1:1 stoichiometric complex with HP-β-CD while UV and IR spectra suggested that HP-β-CD and paeonol in the complex interacted by a non-covalent bond. SEM and XRD indicate that the heat stability of paeonol was significantly improved by complexing with HP-β-CD.

Conclusion: Paeonol can be efficiently complexed with HP-β-CD to form a complex by freeze-drying method. The aqueous solubility and heat stability of paeonol is significantly improved by complexation HP-β-CD.

Keywords: Paeonol, Hydroxypropyl-ß-cyclodextrin, Complexation, Aqueous solubility, Heat stability